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Longevity

FOXO4

≥99.0% HPLC Verified Purity

CAS Number1449830-41-4

Molecular Weight5358.1 Da

Molecular FormulaC₂₂₈H₃₉₀N₈₆O₇₅S₂

Storage−20°C · Lyophilized

$200.00/ vial

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RESEARCH USE ONLY: This compound is intended exclusively for in vitro laboratory research. Not for human or veterinary use. Not intended to diagnose, treat, cure, or prevent any disease. Not evaluated by the FDA. Must be 21+ to purchase.

What is FOXO4-DRI?

FOXO4-DRI is a D-amino acid retro-inverso peptide (DRI) and p53-interaction domain analog. With the molecular formula C₂₂₈H₃₉₀N₈₆O₇₅S₂ and a molecular weight of 5358.1 g/mol (CAS: 1449830-41-4), it structurally mimics endogenous peptides while extending its sequence.

Amino Acid Sequence:D-amino acid sequence matching FOXO4-p53 binding domain

Classification: D-Amino Acid Retro-Inverso Peptide (Dri)FOXO4-p53 InteractionSenescence-associated pathways

Specifications

CAS Number	1449830-41-4
Molecular Formula	C228H390N86O75S2
Molecular Weight	5358.1 Da
Purity	≥99.0% (HPLC verified)
Form	Lyophilized powder
Storage	−20°C · Lyophilized

Published Research

Bourgeois et al. (2025) investigated FOXO4-DRI's binding affinity and receptor interactions in vitro (PMID: 40593617).

PMID: 40593617

Meng et al. (2021) investigated FOXO4-DRI's binding affinity and receptor interactions in vitro (PMID: 34877934).

PMID: 34877934

Mechanism of Action

FOXO4-p53 Interaction

Receptor interaction

Published research demonstrates FOXO4-DRI modulates targeted signaling cascades within cell tissue models (PMID: 40593617).

Senescence-associated pathways

Signaling cascade

In cellular environments, FOXO4-DRI exhibits selective binding and corresponding pathway activation (PMID: 34877934).

Storage & Handling

Temperature:-20°C for long-term storage

Light Sensitivity:Protect from direct light

Stability Duration:Stable for 24 months when stored properly

Research-grade sequence verification via standard assays.

Related Compounds

BPC-157 TB-500 CJC-1295 NO DAC

Research Use Only

All compounds are sold strictly for laboratory research use. Not for human or animal consumption. These products are not drugs, supplements, or food. Statements have not been evaluated by the FDA. Must be 21+ to purchase. This compound is intended exclusively for in vitro laboratory research. Not for human or veterinary use. Not intended to diagnose, treat, cure, or prevent any disease.

Research Catalog

High-purity, structurally verified peptide sequences for advanced laboratory and pre-clinical applications.