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Healing

TB500

≥99.5% HPLC Verified Purity

CAS Number77591-33-4

Molecular Weight4963.5 Da

Molecular FormulaC₂₁₂H₃₅₀N₅₆O₇₈S

Storage−20°C · Lyophilized

$50.00/ vial

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RESEARCH USE ONLY: This compound is intended exclusively for in vitro laboratory research. Not for human or veterinary use. Not intended to diagnose, treat, cure, or prevent any disease. Not evaluated by the FDA. Must be 21+ to purchase.

What is TB-500?

TB-500 (Thymosin Beta-4 Fragment) is a synthetic 43-amino acid peptide representing the active region of the naturally occurring Thymosin Beta-4 protein. With the molecular formula C₂₁₂H₃₅₀N₅₆O₇₈S and a molecular weight of 4963.5 g/mol (CAS: 77591-33-4), TB-500 is the research designation for the peptide fragment containing the primary bioactive sequence of the parent protein.

Amino Acid Sequence:

Ac-Ser-Asp-Lys-Pro-Asp-Met-Ala-Glu-Ile-Glu-Lys-Phe-Asp-Lys-Ser-Lys-Leu-Lys-Lys-Thr-Glu-Thr-Gln-Glu-Lys-Asn-Pro-Leu-Pro-Ser-Lys-Glu-Thr-Ile-Glu-Gln-Glu-Lys-Gln-Ala-Gly-Glu-Ser-OH

Classification: Actin-Binding Peptide FragmentActin CytoskeletonG-Actin Binding

Specifications

CAS Number	77591-33-4
Molecular Formula	C212H350N56O78S
Molecular Weight	4963.5 Da
Purity	≥99.5% (HPLC verified)
Form	Lyophilized powder
Storage	−20°C · Lyophilized

Published Research

Malinda et al. (2004) examined the actin-binding properties of thymosin beta-4 and its effects on keratinocyte migration in vitro (PMID: 15283699).

PMID: 15283699VERIFY PMID

Sosne et al. (2009) investigated TB-4 fragment's effects on corneal epithelial cell migration and integrin expression in cell culture models (PMID: 19189658).

PMID: 19189658VERIFY PMID

Huff et al. (2009) characterized the structure-function relationship of the actin-binding domain within thymosin beta-4 (PMID: 19549937).

PMID: 19549937VERIFY PMID

Mechanism of Action

Actin Cytoskeleton

G-actin sequestration

TB-500 binds to monomeric G-actin, regulating actin polymerization and cytoskeletal dynamics in cell culture models (PMID: 15283699).

Cell Migration

Integrin signaling

Published studies demonstrate effects on cell motility through interactions with integrin receptors and focal adhesion dynamics (PMID: 19189658).

Storage & Handling

Temperature:-20°C for long-term storage

Light Sensitivity:Protect from direct light

Stability Duration:Stable for 24 months when stored properly

Reconstituted solutions should be aliquoted and frozen at -20°C to avoid repeated freeze-thaw cycles.

Related Compounds

BPC-157 GHK-Cu Thymosin Alpha-1

Research Use Only

All compounds are sold strictly for laboratory research use. Not for human or animal consumption. These products are not drugs, supplements, or food. Statements have not been evaluated by the FDA. Must be 21+ to purchase. This compound is intended exclusively for in vitro laboratory research. Not for human or veterinary use. Not intended to diagnose, treat, cure, or prevent any disease.

Research Catalog

High-purity, structurally verified peptide sequences for advanced laboratory and pre-clinical applications.